Artículos por temáticas

The current landscape in Alzheimer's disease research and drug discovery

Devenish SRA.

Drug Discov Today. 2020 Jun;25(6):943-945. doi: 10.1016/j.drudis.2020.04.002. Epub 2020 Apr 28.

Healthy brain, healthy life: a review of diet and exercise interventions to promote brain health and reduce Alzheimer's disease risk

Baranowski BJ, Marko DM, Fenech RK, Yang AJT, MacPherson REK.

Appl Physiol Nutr Metab. 2020 Oct;45(10):1055-1065. doi: 10.1139/apnm-2019-0910. Epub 2020 Jul 27.

Alzheimer's disease; a review of the pathophysiological basis and therapeutic interventions

Abeysinghe AADT, Deshapriya RDUS, Udawatte C.

Life Sci. 2020 Sep 1;256:117996. doi: 10.1016/j.lfs.2020.117996. Epub 2020 Jun 23.

Gut Microbiota and Dysbiosis in Alzheimer's Disease: Implications for Pathogenesis and Treatment

Liu S, Gao J, Zhu M, Liu K, Zhang HL.

Mol Neurobiol. 2020 Dec;57(12):5026-5043. doi: 10.1007/s12035-020-02073-3. Epub 2020 Aug 23.

Autophagy Dysfunction in Alzheimer's Disease: Mechanistic Insights and New Therapeutic Opportunities

Di Meco A, Curtis ME, Lauretti E, Praticò D.

Biol Psychiatry. 2020 May 1;87(9):797-807. doi: 10.1016/j.biopsych.2019.05.008. Epub 2019 May 20.

Blood-based Biomarkers of Alzheimer's Disease: The Long and Winding Road

Manzine PR, Vatanabe IP, Peron R, Grigoli MM, Pedroso RV, Nascimento CMC, Cominetti MR.

Curr Pharm Des. 2020;26(12):1300-1315. doi: 10.2174/1381612826666200114105515.

Risk Reduction and Prevention of Alzheimer's Disease: Biological Mechanisms of Diet

McGurran H, Glenn J, Madero E, Bott N.

Curr Alzheimer Res. 2020;17(5):407-427. doi: 10.2174/1567205017666200624200651.

Development of novel phosphodiesterase 5 inhibitors for the therapy of Alzheimer's disease

Zuccarello E, Acquarone E, Calcagno E, Argyrousi EK, Deng SX, Landry DW, Arancio O, Fiorito J.

Biochem Pharmacol. 2020 Jun;176:113818. doi: 10.1016/j.bcp.2020.113818. Epub 2020 Jan 21.

Drug repositioning and repurposing for Alzheimer disease

Ballard C, Aarsland D, Cummings J, O'Brien J, Mills R, Molinuevo JL, Fladby T, Williams G, Doherty P, Corbett A, Sultana J.

Nat Rev Neurol. 2020 Dec;16(12):661-673. doi: 10.1038/s41582-020-0397-4. Epub 2020 Sep 16.

Integrated meta-analysis, network pharmacology, and molecular docking to investigate the efficacy and potential pharmacological mechanism of Kai-Xin-San on Alzheimer's disease

Yi P, Zhang Z, Huang S, Huang J, Peng W, Yang J.

Pharm Biol. 2020 Dec;58(1):932-943. doi: 10.1080/13880209.2020.1817103.

Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial

Arellanes IC, Choe N, Solomon V, He X, Kavin B, Martinez AE, Kono N, Buennagel DP, Hazra N, Kim G, D'Orazio LM, McCleary C, Sagare A, Zlokovic BV, Hodis HN, Mack WJ, Chui HC, Harrington MG, Braskie MN

EBioMedicine. 2020 Sep;59:102883. doi: 10.1016/j.ebiom.2020.102883. Epub 2020 Jul 17.

A randomized, controlled clinical trial of plasma exchange with albumin replacement for Alzheimer's disease: Primary results of the AMBAR Study

Boada M, López OL, Olazarán J, Núñez L, Pfeffer M, Paricio M, Lorites J, Piñol-Ripoll G, Gámez JE, Anaya F, Kiprov D, Lima J, Grifols C, Torres M, Costa M, Bozzo J, Szczepiorkowski ZM, Hendrix S, Páez

Alzheimers Dement. 2020 Oct;16(10):1412-1425. doi: 10.1002/alz.12137. Epub 2020 Jul 27.

Current Aspects of the Endocannabinoid System and Targeted THC and CBD Phytocannabinoids as Potential Therapeutics for Parkinson's and Alzheimer's Diseases: a Review

Cooray R, Gupta V, Suphioglu C.

Mol Neurobiol. 2020 Nov;57(11):4878-4890. doi: 10.1007/s12035-020-02054-6. Epub 2020 Aug 19.

Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model

Wang S, Mustafa M, Yuede CM, Salazar SV, Kong P, Long H, Ward M, Siddiqui O, Paul R, Gilfillan S, Ibrahim A, Rhinn H, Tassi I, Rosenthal A, Schwabe T, Colonna M.

J Exp Med. 2020 Sep 7;217(9):e20200785. doi: 10.1084/jem.20200785.

How plausible is an Alzheimer's disease vaccine?

Cacabelos R.

Expert Opin Drug Discov. 2020 Jan;15(1):1-6. doi: 10.1080/17460441.2019.1667329. Epub 2019 Sep 17.